Methylamine → 2-(4-Bromo-phenyl)-N-methyl-isobutyramide

HRID 858581

反応式

HRID 858581 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9](O)=[O:10])=[CH:4][CH:3]=1.C(OCC)(=O)CC(O)=O.CN.BrC1C=CC([C@H:32]([NH2:34])C)=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH3:13])([CH3:12])[C:9]([NH:34][CH3:32])=[O:10])=[CH:4][CH:3]=1

参加物

5

反応物 4

HCID 6329MethylamineHCID 70615Monoethyl malonateHCID 853000(R)-4-bromo-alpha-methylbenzylamineHCID 109336792-(4-Bromophenyl)-2-methylpropanoic acid

生成物 1

HCID 587627572-(4-Bromo-phenyl)-N-methyl-isobutyramide収率 84%

実験手順

The title compound was prepared as described in Step 1 of Example A(39), where 2-(4-bromophenyl)-2-methyl propionic acid was substituted for ethyl hydrogen malonate and methyl amine was substituted instead of (R)-(+)-1-(4-bromophenyl)ethylamine on that example. Yield 84%.

出典と根拠

ORDレコード
ord-a025f88052e6471dbade514643702c64
出典データセット
uspto-grants-2006_12
特許番号
US07148226B2

関連ノート

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