2-Fluoro-6-(1-hydroxyethyl)phenol → 2-Ethyl-6-fluorophenol

HRID 858639ノート

反応式

HRID 858639 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:8](O)[CH3:9])[C:3]=1[OH:11]>CO.[Pd]>[CH2:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[C:3]=1[OH:11])[CH3:9]

参加物

4

反応物 1

HCID 450831602-Fluoro-6-(1-hydroxyethyl)phenol

生成物 1

HCID 587626932-Ethyl-6-fluorophenol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 2-fluoro-6-(1-hydroxy-ethyl)-phenol (1.7 g, 10.9 mmol) and 10 wt % Pd/C (0.85 g, Degussa type) in MeOH (30 mL) was stirred under a balloon of H2 for 6 hours. The reaction mixture was filtered through a pad of celite washing with EtOAc. The filtrate was concentrated to a yellow oil (1.35 g, 87%). 1H NMR (400 MHz, CDCl3): δ 1.22 (t, J=7.6 Hz, 3 H), 2.68 (q, J=7.3 Hz, 2 H), 5.12 (s, 1 H), 6.76 (m, 1 H), 6.92 (m, 2 H).

後処理

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. washwashing with EtOAc
  3. concentrationThe filtrate was concentrated to a yellow oil (1.35 g, 87%)

出典と根拠

ORDレコード
ord-9c49735205834ffaa6169852b4219c61
出典データセット
uspto-grants-2006_12
特許番号
US07148226B2

反応ノート

読み込み中…