Nitric Acid → HCID 178468909、化合物
反応式
[N+:1]([O-])([OH:3])=[O:2].[CH2:5]([O:7][C:8](=[O:16])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([NH2:15])[CH:10]=1)[CH3:6].[N:17]#[C:18][NH2:19]>C(O)C>[N:1]([OH:3])=[O:2].[CH2:5]([O:7][C:8]([C:9]1[CH:10]=[C:11]([NH:15][C:18]([NH2:19])=[NH:17])[CH:12]=[CH:13][CH:14]=1)=[O:16])[CH3:6]参加物
5
実験手順
Nitric acid (70%, 6.66 mL) is added to a mixture of 3-amino benzoic acid ethyl ester (17.21 g, 104 mmol) and cyanamide (50% in water, 12.1 mL, 156 mmol) in 50 mL of ethanol. The reaction mixture is heated for 24 hours under reflux. It is then cooled to room temperature and filtered. The solid is washed with water, ether and dried to give 3-ethoxycarbonyl-phenyl-guanidine nitrite as a gray solid; ESI-MS (m/z): 208.1 (M+-HNO3+H).
後処理
- temperatureThe reaction mixture is heated for 24 hours
- temperatureunder reflux
- filtrationfiltered
- washThe solid is washed with water, ether
- customdried
出典と根拠
- ORDレコード
- ord-4f42fc89c4d24dcf89d4fbaf2853fb0d
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07151096B2
反応ノート
読み込み中…