(2'-Fluoro-6'-methoxy-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester → (3-Amino-2'-fluoro-6'-methoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 859339ノート

反応式

HRID 859339 の反応式
[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:19]([O:20][CH3:21])=[CH:18][CH:17]=[CH:16][C:15]=2[F:22])=[CH:10][C:9]=1[N+:23]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:26])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[C:19]([O:20][CH3:21])=[CH:18][CH:17]=[CH:16][C:15]=2[F:22])=[CH:10][C:9]=1[NH2:23])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 69592869(2'-Fluoro-6'-methoxy-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

生成物 1

HCID 69592800(3-Amino-2'-fluoro-6'-methoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Prepared from (2′-fluoro-6′-methoxy-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B16) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a light purple foam (577 mg).

出典と根拠

ORDレコード
ord-ce92c1e20a0c41c1b36805f6d186c344
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

反応ノート

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