(2',3'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester → (3-Amino-2',3'-difluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 859343

反応式

HRID 859343 の反応式
[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=2[F:21])=[CH:10][C:9]=1[N+:22]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:25])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:15]=2[F:21])=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:2])[CH3:3]

参加物

3

反応物 1

HCID 69592780(2',3'-Difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

生成物 1

HCID 69592847(3-Amino-2',3'-difluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester収率 101.4%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

Prepared from (2′,3′-difluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example B19) (3.14 g, 8.96 mmol) by catalytic hydrogenation with Pd/C according to the general procedure G (method a). Obtained as a green solid (2.91 g).

出典と根拠

ORDレコード
ord-1f8bb73436b4480e84f5df14661e942a
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

関連ノート

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