Trifluoroacetic acid → 8-(4-Fluoro-phenylethynyl)-4-(3-tetrazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 859547ノート

反応式

HRID 859547 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)=[CH:10][C:9]=1[NH2:23])(C)(C)C.C(O[C:28](=[O:43])[CH2:29][C:30](=O)[C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([N:37]2[CH:41]=[N:40][N:39]=[N:38]2)[CH:32]=1)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:22][C:19]1[CH:18]=[CH:17][C:16]([C:15]#[C:14][C:11]2[CH:12]=[CH:13][C:8]3[N:7]=[C:30]([C:31]4[CH:36]=[CH:35][CH:34]=[C:33]([N:37]5[CH:41]=[N:40][N:39]=[N:38]5)[CH:32]=4)[CH2:29][C:28](=[O:43])[NH:23][C:9]=3[CH:10]=2)=[CH:21][CH:20]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 69486641[2-Amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert-butyl esterHCID 695927913-Oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester

生成物 1

HCID 98451278-(4-Fluoro-phenylethynyl)-4-(3-tetrazol-1-yl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Prepared from [2-amino-4-(4-fluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example G33) and 3-oxo-3-(3-tetrazol-1-yl-phenyl)-propionic acid ethyl ester (Example H15) according to the general procedure K. The obtained material was deprotected and cyclized by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a beige powder (5.5 mg).

出典と根拠

ORDレコード
ord-b68747766c3343d6829ef30b248f3956
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

反応ノート

読み込み中…