Trifluoroacetic acid → (E)-3-(7-(2-(2,4-difluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile

HRID 859589ノート

反応式

HRID 859589 の反応式
C(OC(=O)[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]#[C:15][C:16]2C=C[C:19]([F:22])=[CH:18][C:17]=2F)=[CH:10][C:9]=1[NH:24][C:25](=[O:37])[CH2:26][C:27]([C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([C:35]#[N:36])[CH:30]=1)=O)(C)(C)C.[C:39](O)([C:41]([F:44])(F)F)=O>C(Cl)Cl>[F:44][C:41]1[CH:39]=[C:19]([F:22])[CH:18]=[CH:17][C:16]=1[C:15]#[C:14][C:11]1[CH:12]=[CH:13][C:8]2[N:7]=[C:27]([C:29]3[CH:30]=[C:31]([CH:32]=[CH:33][CH:34]=3)[C:35]#[N:36])[CH2:26][C:25](=[O:37])[NH:24][C:9]=2[CH:10]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86588080[2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-(2,4-difluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester

生成物 1

HCID 22224756(E)-3-(7-(2-(2,4-difluorophenyl)ethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)benzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Prepared from [2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-(2,4-difluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester (Example K96) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a light yellow solid (87 mg).

出典と根拠

ORDレコード
ord-870de705ec0244b2b2d06ed5da44659a
出典データセット
uspto-grants-2006_12
特許番号
US07151098B2

反応ノート

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