HCID 57481298、化合物 → HCID 57444485、化合物

HRID 860409ノート

反応式

HRID 860409 の反応式
[C:1]([C:4]([C:21](=[O:30])[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]#[N:29])[CH:23]=1)([CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])C(OC(C)(C)C)=O)(=[O:3])[CH3:2]>FC(F)(F)C(O)=O>[C:28]([C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[C:21]([CH:4]([C:1](=[O:3])[CH3:2])[CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[O:30])#[N:29]

参加物

3

反応物 1

HCID 57481298HCID 57481298、化合物

生成物 1

HCID 57444485HCID 57444485、化合物収率 100.4%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

To 1-tert-butyl 7-ethyl 2-acetyl-2-(3-cyanobenzoyl)-heptanedioate (4.2 g) was added trifluoroacetic acid (20 mL) in an ice-water bath. After 30 minutes, the bath was removed and the reaction mixture was stirred at ambient temperature. After 1 hour, the mixture was concentrated. The residue was dissolved in toluene and was evaporated in vacuo to give ethyl 6-(3-cyanobenzoyl)-7-oxooctanoate (3.20 g, 100.4%) as colorless oil.

後処理

  1. customthe bath was removed
  2. waitAfter 1 hour
  3. concentrationthe mixture was concentrated
  4. dissolutionThe residue was dissolved in toluene
  5. customwas evaporated in vacuo

出典と根拠

ORDレコード
ord-a89fb8cb084d440fbd91b539f5a1de6e
出典データセット
uspto-grants-2006_12
特許番号
US07153854B2

反応ノート

読み込み中…