Water → HCID 57444530、化合物

HRID 860416ノート

反応式

HRID 860416 の反応式
[C:1]([C:4]([C:18](=[O:27])[C:19]1[CH:24]=[CH:23][C:22]([C:25]#[N:26])=[CH:21][CH:20]=1)(C(=O)C)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:3])[CH3:2].C(OCC)(=O)C.O>FC(F)(F)C(O)=O>[C:25]([C:22]1[CH:21]=[CH:20][C:19]([C:18]([CH:4]([C:1](=[O:3])[CH3:2])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:27])=[CH:24][CH:23]=1)#[N:26]

参加物

5

反応物 3

HCID 962WaterHCID 8857Ethyl AcetateHCID 57444529Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate

生成物 1

HCID 57444530HCID 57444530、化合物収率 72.5%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
20 °C

実験手順

Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate (3.5 g) was dissolved in trifluoroacetic acid (12.6 ml) and the mixture was stirred at 20° C. for 15 minutes. The mixture was partitoned between ethyl acetate and water. The organic layer was separated, washed with water, aqueous sodium bicarbonate and brine, dried over MgSO4 (magnesium sulfate), and evaporated to give ethyl 7-(4-cyanobenzoyl)-8-oxononanoate (2.25 g) as an oil.

後処理

  1. customThe organic layer was separated
  2. washwashed with water, aqueous sodium bicarbonate and brine
  3. dry with materialdried over MgSO4 (magnesium sulfate)
  4. customevaporated

出典と根拠

ORDレコード
ord-e00be75486dc4cbcb2c46c3115462fa4
出典データセット
uspto-grants-2006_12
特許番号
US07153854B2

反応ノート

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