Water → 3-Bromo-4-(methoxycarbonyl)benzoic acid

HRID 860497

反応式

HRID 860497 の反応式
[Br:1][C:2]1[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[OH-].[Na+].O>CO>[Br:1][C:2]1[CH:11]=[C:10]([CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])[C:12]([OH:14])=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 87741Dimethyl 2-bromoterephthalate

生成物 1

HCID 186730263-Bromo-4-(methoxycarbonyl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of dimethyl 2-bromoterephthalate (1.04 g) in methanol (10 mL) was added 1 N sodium hydroxide (5.71 mL) at room temperature. After stirring for 1.5 hour, the reaction was quenched by adding 1 N hydrochloric acid (7 mL). White crystals were formed. Water (10 mL) was added to aid crystalyzation. The crystals were collected by filtration, washed with water, and dried in the air. 3-Bromo-4-(methoxycarbonyl)benzoic acid was obtained as white crystals (532 mg).

後処理

  1. customthe reaction was quenched
  2. additionby adding 1 N hydrochloric acid (7 mL)
  3. customWhite crystals were formed
  4. filtrationThe crystals were collected by filtration
  5. washwashed with water
  6. customdried in the air

出典と根拠

ORDレコード
ord-06faeda32f094272805e9b2f1b23a5e7
出典データセット
uspto-grants-2006_12
特許番号
US07153854B2

関連ノート

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