Water → 3-Bromo-4-(methoxycarbonyl)benzoic acid
反応式
[Br:1][C:2]1[CH:11]=[C:10]([C:12]([O:14]C)=[O:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[OH-].[Na+].O>CO>[Br:1][C:2]1[CH:11]=[C:10]([CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5])[C:12]([OH:14])=[O:13]参加物
5
実験手順
To a solution of dimethyl 2-bromoterephthalate (1.04 g) in methanol (10 mL) was added 1 N sodium hydroxide (5.71 mL) at room temperature. After stirring for 1.5 hour, the reaction was quenched by adding 1 N hydrochloric acid (7 mL). White crystals were formed. Water (10 mL) was added to aid crystalyzation. The crystals were collected by filtration, washed with water, and dried in the air. 3-Bromo-4-(methoxycarbonyl)benzoic acid was obtained as white crystals (532 mg).
後処理
- customthe reaction was quenched
- additionby adding 1 N hydrochloric acid (7 mL)
- customWhite crystals were formed
- filtrationThe crystals were collected by filtration
- washwashed with water
- customdried in the air
出典と根拠
- ORDレコード
- ord-06faeda32f094272805e9b2f1b23a5e7
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07153854B2
反応ノート
読み込み中…