Water → 3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
反応式
[CH3:1][O:2][C:3](=[O:15])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12]Cl)=[CH:8][C:7]=1[CH3:14].[N-:16]=[N+:17]=[N-:18].[Na+].O>CN(C=O)C>[CH3:1][O:2][C:3](=[O:15])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][N:16]=[N+:17]=[N-:18])=[CH:8][C:7]=1[CH3:14]参加物
5
実験手順
To a solution of 3-(4-Chloromethyl-2-methyl-phenyl)-propionic acid methyl ester (0.52 g, 2.31 mmol) in DMF (7 mL) is added sodium azide (0.25 g, 3.84 mmol). The mixture is stirred overnight. Water is added, and the mixture is extracted with EtOAc. The organics are dried with Na2SO4 and concentrated to yield the title compound (0.49 g, 91%). The material is used without further purification.
後処理
- extractionthe mixture is extracted with EtOAc
- dry with materialThe organics are dried with Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-5304e71abee043bd9ca98bd9be0a0fa4
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07153878B2
反応ノート
読み込み中…