Hydrogen Peroxide → 4-Phenyl-3-(4-pyridyl)-3,4-epoxy-2-butanone
反応式
[C:1]1([CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:9](=[O:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:18]O.[OH-].[Na+]>CO>[C:1]1([CH:7]2[O:18][C:8]2([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[C:9](=[O:11])[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
5
実験手順
Using the procedure of Example A-1, step 2, a solution of 4-phenyl-3-(4-pyridyl)-3-butene-2-one (step 2) (1.25 g, 5.6 mmol) in methanol (20 ml) was treated with 30% aqueous hydrogen peroxide (1 ml) in the presence of sodium hydroxide (230 mg, 5.7 mmol). The crude product was purified by chromatography (silica gel, 1:1 ethyl acetate/hexane) to give 4-phenyl-3-(4-pyridyl)-3,4-epoxy-2-butanone (270 mg, 20%).
後処理
- customThe crude product was purified by chromatography (silica gel, 1:1 ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-d5973da4321541e2b0852ac87efbef45
- 出典データセット
- uspto-grants-2006_12
- 特許番号
- US07153959B2
反応ノート
読み込み中…