Hydrochloric Acid → N1-hexanoylsulfanilamide

HRID 861186

反応式

HRID 861186 の反応式
C(NC1C=CC(S(N)(=O)=O)=CC=1)(=O)C.C(Cl)(=O)CCCCC.Cl.C([NH:27][C:28]1[CH:44]=[CH:43][C:31]([S:32]([NH:35][C:36](=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41])(=[O:34])=[O:33])=[CH:30][CH:29]=1)(=O)C>O.N1C=CC=CC=1>[C:36]([NH:35][S:32](=[O:33])([C:31]1[CH:30]=[CH:29][C:28]([NH2:27])=[CH:44][CH:43]=1)=[O:34])(=[O:42])[CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 8482N4-AcetylsulfanilamideHCID 67340Hexanoyl chlorideHCID 54008860HCID 54008860、化合物

生成物 1

HCID 14338356N1-hexanoylsulfanilamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1049Pyridine溶媒

実験手順

N1 -hexanoylsulfanilamide was prepared as follows. To a mixture of N4 -acetylsulfanilamide (55.0 g) and pyridine (54 mL) at 95° C. was added hexanoyl chloride (28.8 g) over a period of 20 min. After an additional hour the reaction mixture was cooled to room temperature and the reaction was worked up by diluting with 600 mL D.I. water and acidifying with aqueous HCl. The product of this reaction, N4 -acetyl-N1 -hexanoylsulfanilamide, was isolated by filtration and washed with D.I. water (700 mL) to afford an off-white solid. This material was carried directly to the next step.

後処理

  1. additionby diluting with 600 mL D.I
  2. customwas isolated by filtration
  3. washwashed with D.I
  4. customwater (700 mL) to afford an off-white solid

出典と根拠

ORDレコード
ord-4ae0af2c5247494da797655fdc01bac6
出典データセット
uspto-grants-1998_02
特許番号
US05713988

関連ノート

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