di t-butyl 4-nitrobenzylcarbonyl-L-glutamate → di t-butyl 4-aminobenzylcarbonyl-L-glutamate

HRID 861218ノート

反応式

HRID 861218 の反応式
[N+:1]([CH:4]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:5][C@@H:6]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[NH:7][C:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:9])([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:1][CH:4]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:5][C@@H:6]([C:17]([O:19][C:20]([CH3:23])([CH3:21])[CH3:22])=[O:18])[NH:7][C:8]([CH2:10][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[O:9]

参加物

4

反応物 1

HCID 86748613di t-butyl 4-nitrobenzylcarbonyl-L-glutamate

生成物 1

HCID 86748612di t-butyl 4-aminobenzylcarbonyl-L-glutamate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of di t-butyl 4-nitrobenzylcarbonyl-L-glutamate (9.7 g) in ethyl acetate (200 ml) was hydrogenated over 30% Pd/C (900 mg). The mixture was then filtered through Celite and evaporated to yield a yellow oil (di t-butyl 4-aminobenzylcarbonyl-L-glutamate) which was used without further purification. NMR: 8.23(d)1H; 6.92(d)2H; 6.50(d) 2H; 4.86(s) 2H; 4.15(m)1H; 3.24(s) 2H; 2.22(m)2H; 1.8(m)2H); 1.4(d)18H. Yield 8.2 g 90%.

後処理

  1. filtrationThe mixture was then filtered through Celite
  2. customevaporated

出典と根拠

ORDレコード
ord-b9f95fb576a44848b3968814ebe32d3b
出典データセット
uspto-grants-1998_02
特許番号
US05714148

反応ノート

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