Aluminium lithium hydride → HCID 45099445、化合物
反応式
C[O:2][C:3]([C@@H:5]1[CH2:14][N:8]2[CH2:9][CH2:10][NH:11][C:12](=O)[C@@H:7]2[CH2:6]1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[OH:2][CH2:3][C@@H:5]1[CH2:14][N:8]2[CH2:9][CH2:10][NH:11][CH2:12][C@@H:7]2[CH2:6]1参加物
4
実験手順
A solution of 1.75 g (8.84 mmol) of (7S,8aS)-7-methoxycarbonyl-1,2,3,4,6,7,8,8 a-octahydro-pyrrolo[1,2-a]pyrazin-1-one (Preparation 11) in 100 mL of THF was added dropwise to a suspension of 0.67 g (18 mmol) of lithium aluminum hydride in 100 mL of refluxing THF. After stirring for 1 h, the solution was cooled and carefully quenched with 0.67 mL of water, 0.67 mL of 15% sodium hydroxide, and 2.0 mL of water. The precipitate was filtered and the filtrate was concentrated to give 1.4 g of (7S,8aS)-7-hydroxymethyl-1,2,3,4,6,7,8,8a-octahydro-pyrrolo[1,2-a]pyrazine of sufficient purity for use in subsequent reactions.