Acetyl chloride → 2-Allyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol
反応式
[C:1](Cl)(=O)[CH3:2].[CH2:5]([C:8]1[CH:9]=[C:10]([CH:15]=[CH:16][C:17]=1[OH:18])[C:11](=[N:13][OH:14])[NH2:12])[CH:6]=[CH2:7]>N1C=CC=CC=1>[CH2:5]([C:8]1[CH:9]=[C:10]([C:11]2[N:12]=[C:1]([CH3:2])[O:14][N:13]=2)[CH:15]=[CH:16][C:17]=1[OH:18])[CH:6]=[CH2:7]参加物
4
実験手順
Acetyl chloride (2.28 ml) was added dropwise to a solution of 3-allyl-4-hydroxybenzamidoxime (5.4 g) in pyridine (48 ml). The solution was heated at reflux for 16 hours, cooled to ambient temperature and evaporated. The residue was dissolved in ethyl acetate and the solution was washed with saturated aqueous sodium carbonate solution, dried (MgSO4) and evaporated, to give 2-allyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol as a low-melting solid (3.8 g), m/z 217 (M+H).
後処理
- temperatureThe solution was heated
- temperatureat reflux for 16 hours
- customevaporated
- dissolutionThe residue was dissolved in ethyl acetate
- washthe solution was washed with saturated aqueous sodium carbonate solution
- dry with materialdried (MgSO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-7390b4b2ffc34ea8b1fd4bfabde9e5ff
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05714496
反応ノート
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