Benzoyl chloride → HCID 22097203、化合物

HRID 861540ノート

反応式

HRID 861540 の反応式
[CH3:1][O:2][CH:3]1[CH:7]([CH2:8][NH2:9])[CH2:6][CH:5]([O:10][CH3:11])[O:4]1.C(N(CC)CC)C.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O1CCCC1>[C:19]([NH:9][CH2:8][CH:7]1[CH2:6][CH:5]([O:10][CH3:11])[O:4][CH:3]1[O:2][CH3:1])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 21710167HCID 21710167、化合物

生成物 1

HCID 22097203HCID 22097203、化合物収率 73%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

2 g (12.4 mmol) of 2,5-dimethoxy-3-aminomethyltetrahydrofuran and 3.4 ml (24.8 mmol) of triethylamine were dissolved in 50 ml of anhydrous tetrahydrofuran. At 0° C., 1.7 g (12.4 mmol) of benzoyl chloride dissolved in 20 ml of anhydrous tetrahydrofuran were added dropwise. The mixture was stirred for 1 h and then filtered, and the filtrate was concentrated under reduced pressure. The residue was reprecipitated from ether/petroleum ether to yield 2.4 g of impure product which was used in the next step.

後処理

  1. additionwere added dropwise
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was reprecipitated from ether/petroleum ether

出典と根拠

ORDレコード
ord-16153176cdfc4bc5813836f0b9ff939b
出典データセット
uspto-grants-1998_02
特許番号
US05714489

反応ノート

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