Nitric Acid → 6-Acetylamino-2-methyl-3-nitro-benzoic acid
反応式
[N+:1]([O-:4])(O)=[O:2].[CH3:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]>O>[CH3:5][C:6]1[C:14]([N+:1]([O-:4])=[O:2])=[CH:13][CH:12]=[C:11]([NH:15][C:16](=[O:18])[CH3:17])[C:7]=1[C:8]([OH:10])=[O:9]参加物
4
反応条件
- 温度
- 10 °C
実験手順
271 ml of 98 percent nitric acid are initially taken at -5° C. and 106 g (0.55 mol) of the 2-methyl-6-acetamidobenzoic acid prepared in 1. are added in portions. After stirring at 10° C. for one hour, the reaction mixture is poured into a mixture of 540 g of ice and 270 ml of water. The deposited precipitate is filtered off with suction, washed with water and dried under reduced pressure at 50° C. Yield: 75.6 g (0.317 mol)=58% of theory, m.p.: 190°-191° C.
後処理
- customare initially taken at -5° C.
- additionare added in portions
- filtrationThe deposited precipitate is filtered off with suction
- washwashed with water
- customdried under reduced pressure at 50° C
出典と根拠
- ORDレコード
- ord-9716e55d2ac04fd39e0caafa0651f2da
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05716905
反応ノート
読み込み中…