Ethanol → (5-Nitrothiophen-2-yl)methanol
反応式
[BH4-].[Na+].[N+:3]([C:6]1[S:10][C:9]([CH:11]=[O:12])=[CH:8][CH:7]=1)([O-:5])=[O:4].C(O)C>O>[OH:12][CH2:11][C:9]1[S:10][C:6]([N+:3]([O-:5])=[O:4])=[CH:7][CH:8]=1参加物
5
実験手順
Sodium borohydride (0.24 g) was added to a mixture of 5-nitro-2-thiophenecarboxaldehyde (1.0 g) and ethanol (30 ml) at 0° C. and then this mixture was stirred at the same temperature for 40 minutes. The reaction mixture was poured into water and extracted with dichloromethane. The dichloromethane layer was washed with water and dried (MgSO4), after which the solvent was evaporated off, to yield 2-hydroxymethyl-5-nitrothiophene (0.5 g, 49%).
後処理
- extractionextracted with dichloromethane
- washThe dichloromethane layer was washed with water
- dry with materialdried (MgSO4)
- customafter which the solvent was evaporated off
出典と根拠
- ORDレコード
- ord-fef0c22ab45f4222947122e29012b79a
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05716944
反応ノート
読み込み中…