Hydrochloric Acid → (R)-1-(3-(9H-Tribenz[b,d,f]azepine-9-yl)propyl)-3-piperidinecarboxylic acid, hydrochloride

The above ester (0.13 g, 0.27 mmol) was dissolved in ethanol (3 ml) and 2N sodium hydroxide (0.6 ml). The mixture was stirred at room temperature for 1.5 hour, acidified by addition of 1N hydrochloric acid (pH 1) and ethanol was removed in vacuo. The aqueous solution was diluted with water (10 ml), washed with diethyl ether (20 ml) and extracted with dichloromethane (30 ml). The organic extract was dried (MgSO4) and concentrated in vacuo to afford 90 mg (74%) of the title compound as a solid.

1. customwas removed in vacuo
2. additionThe aqueous solution was diluted with water (10 ml)
3. washwashed with diethyl ether (20 ml)
4. extractionextracted with dichloromethane (30 ml)
5. extractionThe organic extract
6. dry with materialwas dried (MgSO4)
7. concentrationconcentrated in vacuo

ORDレコード

ord-77571e7262b9455bb2c38e4b470233f3

出典データセット

uspto-grants-1998_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05716949