Ethyl Bromide → 2-Ethoxybenzonitrile

HRID 8620

反応式

HRID 8620 の反応式
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(=O)([O-])[O-].[K+].[K+].[CH2:16](Br)[CH3:17]>CC(C)=O>[CH2:16]([O:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5])[CH3:17]

参加物

5

反応物 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 119072-Hydroxybenzonitrile

生成物 1

HCID 5769222-Ethoxybenzonitrile収率 97.1%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

25 g (210 mmol) of 2-hydroxylbenzonitrile are heated, together with 87 g of potassium carbonate and 34.3 g (314.8 mmol) of ethyl bromide, in 500 ml of acetone under reflux overnight. The solid is filtered off, the solvent is removed in vacuo and the residue is distilled in vacuo. 30.0 g (97%) of a colorless liquid are obtained.

後処理

  1. temperatureunder reflux overnight
  2. filtrationThe solid is filtered off
  3. customthe solvent is removed in vacuo
  4. distillationthe residue is distilled in vacuo

出典と根拠

ORDレコード
ord-ce3fd0b48b39417c9f1ac902d61127bf
出典データセット
uspto-grants-2006_08
特許番号
US07091203B2

関連ノート

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