Sodium borohydride → Benzenemethanol, 5-bromo-2-(methoxymethoxy)-

HRID 862056ノート

反応式

HRID 862056 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH:7]=[O:8].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH2:11][O:12][CH3:13])=[C:6]([CH:9]=1)[CH2:7][OH:8]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 197016265-Bromo-2-(methoxymethoxy)benzaldehyde

生成物 1

HCID 54142346Benzenemethanol, 5-bromo-2-(methoxymethoxy)-収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 5-bromo-2-methoxymethoxybenzaldehyde (5.00 g) in methanol (50 ml) was added, at 0° C., sodium borohydride (0.46 g). The mixture was stirred for 30 minutes at the same temperature, which was then concentrated. To the concentrate was added ethyl acetate, and the mixture was washed with an aqueous solution of potassium hydrogensulfate and a saturated aqueous saline solution, successively. The organic layer was dried (anhydrous magnesium sulfate), which was then concentrated to leave 5-bromo-2-methoxymethoxybenzyl alcohol (5.04 g) as a pale yellow oily product.

後処理

  1. concentrationwas then concentrated
  2. additionTo the concentrate was added ethyl acetate
  3. washthe mixture was washed with an aqueous solution of potassium hydrogensulfate
  4. dry with materialThe organic layer was dried (anhydrous magnesium sulfate), which
  5. concentrationwas then concentrated

出典と根拠

ORDレコード
ord-0a810795ea7145fd8dc67a46d3fa7d98
出典データセット
uspto-grants-1998_02
特許番号
US05716971

反応ノート

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