Dicyclohexylcarbodiimide → N-(2-pyridylmethyl)benzhydrylsulphinylacetamide

HRID 862607

反応式

HRID 862607 の反応式
[CH:1]([S:14]([CH2:16][C:17]([OH:19])=O)=[O:15])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[N:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[CH2:21][NH:20][C:17](=[O:19])[CH2:16][S:14]([CH:1]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:15]

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 195092-PyridinemethanamineHCID 3085267Modafinil acid

生成物 1

HCID 15225687N-(2-pyridylmethyl)benzhydrylsulphinylacetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a suspension of 15.44 g (0.06 mol) of benzhydrylsulphinylacetic acid in 90 ml of methylene chloride are added 6.48 g (0.06 mol, i.e. 6.17 ml) of 2-aminomethylpyridine and 12.36 g (0.06 mol) of dicyclohexylcarbodiimide are added to the solution thus obtained. The mixture is heated at reflux for about 3 to 4 hours, then left to cool.

後処理

  1. additionare added to the solution
  2. customthus obtained
  3. temperatureThe mixture is heated
  4. temperatureat reflux for about 3 to 4 hours
  5. waitleft
  6. temperatureto cool

出典と根拠

ORDレコード
ord-6769afe3f93e45529751b5d6b490635d
出典データセット
uspto-grants-1998_02
特許番号
US05719168

関連ノート

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