1,2-Dichloroethane → N-{[7-(4-t-Butoxycarbonylpiperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone-2-yl]acetyl}-3(S)-(3-pyridyl)-beta-alanine ethyl ester

反応式

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:23]=[C:22]3[C:17]([CH2:18][CH2:19][N:20]([CH2:25][C:26](O)=[O:27])[C:21]3=[O:24])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.Cl.[NH2:31][C@H:32]([C:39]1[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=1)[CH2:33][C:34]([O:36][CH2:37][CH3:38])=[O:35].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1.CN1CCOCC1.[Li+].[OH-]>CN(C=O)C.CCOC(C)=O.O.CO>[CH2:37]([O:36][C:34](=[O:35])[CH2:33][C@@H:32]([C:39]1[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=1)[NH:31][C:26](=[O:27])[CH2:25][N:20]1[CH2:19][CH2:18][C:17]2[C:22](=[CH:23][C:14]([N:11]3[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:2])([CH3:4])[CH3:3])=[O:7])[CH2:13][CH2:12]3)=[CH:15][CH:16]=2)[C:21]1=[O:24])[CH3:38]