2-Methoxyethylamine → 4-Ethoxy-N-(2-methoxy-ethyl)-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzenesulfonamide
反応式
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15](Cl)(=[O:17])=[O:16])=[CH:11][C:10]=1[C:19]1[NH:24][C:23](=[O:25])[N:22]2[C:26]([CH3:32])=[N:27][C:28]([CH2:29][CH2:30][CH3:31])=[C:21]2[N:20]=1)[CH3:7]>ClCCl>[CH2:6]([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([NH:5][CH2:4][CH2:3][O:2][CH3:1])(=[O:17])=[O:16])=[CH:11][C:10]=1[C:19]1[NH:24][C:23](=[O:25])[N:22]2[C:26]([CH3:32])=[N:27][C:28]([CH2:29][CH2:30][CH3:31])=[C:21]2[N:20]=1)[CH3:7]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
55 mg (0.73 mmol) of 2-methoxyethylamine are added to a solution of 100 mg (0.24 mmol) of 4-ethoxy-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzenesulfonyl chloride (example VI) in 5 ml of dichloromethane and the reaction mixture is stirred at room temperature for 2 hours. After chromatographic purification (dichloromethane/methanol=95:5) and stirring up with diethyl ether, 64 mg (57%) of 4-ethoxy-N-(2-methoxy-ethyl)-3-(6-methyl-4-oxo-8-propyl-3,4-dihydro-imidazo[1,5-a][1,3,5]triazin-2-yl)-benzenesulfonamide are obtained.