2-Chloro-5-nitroanisole → 2-Chloro-5-nitrophenol

HRID 8629

反応式

HRID 8629 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[O:11]C>Br.CC(O)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11]

参加物

4

反応物 1

HCID 705192-Chloro-5-nitroanisole

生成物 1

HCID 692642-Chloro-5-nitrophenol

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

実験手順

2-Chloro-5-nitroanisole (310 g, 1.7 mol) was taken up in a mixture of 48% HBr (1.5 L) and AcOH (1.2 L) and heated at reflux for 3 days. The dark solution was allowed to cool to room temperature, poured into ice water (10 L), and let stand for 3 h. The resultant dull yellow solid was filtered, washed with water, and dried in vacuo (230 g, 79%): mp 115–117° C.

後処理

  1. temperatureheated
  2. temperatureat reflux for 3 days
  3. filtrationThe resultant dull yellow solid was filtered
  4. washwashed with water
  5. customdried in vacuo (230 g, 79%)

出典と根拠

ORDレコード
ord-9fdbebea0cd2417a98d35f38d61d0e08
出典データセット
uspto-grants-2006_08
特許番号
US07091204B2

関連ノート

読み込み中…