Thionyl Chloride → 4-[(2-methylbenzoyl)amino]benzoyl Chloride

HRID 863006ノート

反応式

HRID 863006 の反応式
[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](O)=[O:12])=[CH:9][CH:8]=1)=[O:5].S(Cl)([Cl:22])=O>>[CH3:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[C:4]([NH:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([Cl:22])=[O:12])=[CH:9][CH:8]=1)=[O:5]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 116158144-[(2-methylbenzoyl)amino]benzoic Acid

生成物 1

HCID 107074414-[(2-methylbenzoyl)amino]benzoyl Chloride

実験手順

A mixture of 10.3 g of 4-[(2-methylbenzoyl)-amino]benzoic acid and 32 ml of thionyl chloride is refluxed for 1.5 hours. The solution is concentrated under vacuum. Toluene is added and the solvent removed under vacuum. Toluene is added and the mixture chilled and filtered to give a yellow solid, m.p. 135°-141° C.

後処理

  1. temperatureis refluxed for 1.5 hours
  2. concentrationThe solution is concentrated under vacuum
  3. additionToluene is added
  4. customthe solvent removed under vacuum
  5. additionToluene is added
  6. temperaturethe mixture chilled
  7. filtrationfiltered
  8. customto give a yellow solid, m.p. 135°-141° C.

出典と根拠

ORDレコード
ord-3d83fe195c6b467cafe01de43fbc7e57
出典データセット
uspto-grants-1998_02
特許番号
US05719278

反応ノート

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