Sodium Hydroxide → HCID 18387469、化合物

HRID 863013ノート

反応式

HRID 863013 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([N:9](C(=O)C1C=C(F)C=CC=1C)[C:10]1[N:15]=[CH:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=1)=[O:8].[OH-].[Na+]>CO.O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:31])=[C:6]([CH:30]=1)[C:7]([NH:9][C:10]1[N:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22099733Methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate

生成物 1

HCID 18387469HCID 18387469、化合物収率 81.2%

試薬・触媒・溶媒 1

HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

A mixture of 12.0 g of methyl 6-[[bis(5-fluoro-2-methylbenzoyl)]amino]pyridine-3-carboxylate, 60 ml of methanol-tetrahydrofuran (1:1) and 23 ml of 5 N NaOH is stirred at room temperature for 16 hours. The mixture is concentrated under vacuum, diluted with 25 ml of water, cooled and acidified with 1N HCl. The mixture is filtered and the solid washed with water to give 6.3 g of the product as a white solid.

後処理

  1. concentrationThe mixture is concentrated under vacuum
  2. additiondiluted with 25 ml of water
  3. temperaturecooled
  4. filtrationThe mixture is filtered
  5. washthe solid washed with water

出典と根拠

ORDレコード
ord-62b6898baa864e8dab762635617b313d
出典データセット
uspto-grants-1998_02
特許番号
US05719278

反応ノート

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