Hydrochloric Acid → Creatine Monohydrate

温度

95 °C

277.7 g (1 mole) of a technical 40% by weight aqueous sodium sarcosinate solution were used. A pH value of 9.6 (at 20° C.) was adjusted with concentrated hydrochloric acid and heated to 95° C. Subsequently, 105.1 g (1.25 mole) of a technical 50% by weight aqueous cyanamide solution were added thereto with intensive stirring in such a manner that the internal temperature did not exceed 95° C. After ending of the cyanamide addition, further heating was carried out for 1 hour at 95° C. The reaction mixture was then cooled to 15° C. the crystalline precipitate was filtered off with suction and washed chloride-free by washing twice with, in each case, 120 ml of water. The residue was recrystallized from water and dried at 80° C. and 20 mbar. The yield of creatine was 73.4 g (56% of theory). The content determination by means of HPLC gave a content of 100% (creatine monohydrate obtainable pure in chemical commerce was used as standard).

1. customA pH value of 9.6 (at 20° C.)
2. customdid not exceed 95° C
3. temperaturefurther heating
4. temperatureThe reaction mixture was then cooled to 15° C. the crystalline precipitate
5. filtrationwas filtered off with suction
6. washwashed chloride-free
7. washby washing twice with, in each case, 120 ml of water
8. customThe residue was recrystallized from water
9. customdried at 80° C.

ORDレコード

ord-df7ea1d4ddf24e02a917b1f0556d1117

出典データセット

uspto-grants-1998_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05719319