Cyanamide → Creatine Monohydrate

温度

50 °C

462.5 g (1.67 moles) of a technical 40% by weight aqueous sodium sarcosinate solution and 200 g of water were take. A pH value of 9.81 (at 20° C.) was adjusted with concentrated 98% by weight formic acid. The reaction mixture was heated to 50° C. 138.2 g (1.65 moles) of SKW cyanamide L 500 (technical aqueous cyanamide solution with a content of 50.2% by weight) were added uniformly with vigorous stirring at an internal temperature of 50° to 52° C. over the course of 3 hours. The reaction mixture was further stirred for 1 hour at an internal temperature of 50° C. Subsequently, the reaction product was filtered off with suction and, without washing, suspended in 330 g of water. The suspension was stirred for 2 hours at 20° C. It was then filtered off with suction and the residue washed twice with 100 ml of water. After drying in a vacuum at 30° C. and 20 mbar pressure, there were obtained 165.2 g (67.1% of theory) creatine monohydrate.

1. customA pH value of 9.81 (at 20° C.)
2. concentrationwith concentrated 98% by weight formic acid
3. stirringThe reaction mixture was further stirred for 1 hour at an internal temperature of 50° C
4. filtrationSubsequently, the reaction product was filtered off with suction
5. washwithout washing
6. stirringThe suspension was stirred for 2 hours at 20° C
7. filtrationIt was then filtered off with suction
8. washthe residue washed twice with 100 ml of water
9. customAfter drying in a vacuum at 30° C.

ORDレコード

ord-e5face0d94c245cfbacd48f972a4367b

出典データセット

uspto-grants-1998_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05719319