Pyridine → 3-Methylcarbonyloxyquinoline

HRID 863260

反応式

HRID 863260 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[OH:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2.N1C=CC=CC=1.C(Cl)Cl>O>[CH3:2][C:1]([O:5][C:6]1[CH:7]=[N:8][C:9]2[C:14]([CH:15]=1)=[CH:13][CH:12]=[CH:11][CH:10]=2)=[O:3]

参加物

6

反応物 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 113763-Hydroxyquinoline

生成物 1

HCID 154938353-Methylcarbonyloxyquinoline

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

1.35 ml of acetyl chloride are added dropwise to a mixture of 2.5g of 3-hydroxyquinoline (prepared by the method described by Mills and Watson in J.Chem. Soc., 97, 753 (1910)), 8.6 ml of pyridine and 50 ml of methylene chloride, while cooling with ice. After the reaction mixture has been stirred at room temperature for 10 minutes, 50 ml of water are added. Customary working up and purification of the crude product by FC over 50 g of silica gel (mobile phase C) gives 3-methylcarbonyloxyquinoline: Rf (A)=0.55; IR (CH2Cl2): 1770(s) cm-1.

後処理

  1. customprepared by the method
  2. custompurification of the crude product by FC over 50 g of silica gel (mobile phase C)

出典と根拠

ORDレコード
ord-6a16a314908e48289e1152442eec1cdc
出典データセット
uspto-grants-1998_02
特許番号
US05719141

関連ノート

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