Methyl iodide → 3-Methoxyquinoline
反応式
[C:1](=O)([O-])[O-].[K+].[K+].CI.[OH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2>CN(C)C=O.C(OCC)C>[CH3:1][O:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2参加物
6
実験手順
1.05 g of anhydrous potassium carbonate and 0.48 ml of methyliodide are added to a solution of 1.0 g of 3-hydroxyquinoline in 8.5 ml of dimethylformamide and the reaction mixture is stirred at room temperature for 18 h. It is diluted with diethyl ether, the resulting suspension is filtered and the filtrate is concentrated. The crude product is purified by FC over 60 g of silica gel (mobile phase F) to give 3-methoxyquinoline: Rf (A)=0.53.
後処理
- filtrationthe resulting suspension is filtered
- concentrationthe filtrate is concentrated
- customThe crude product is purified by FC over 60 g of silica gel (mobile phase F)
出典と根拠
- ORDレコード
- ord-8ee420d42c2148ab89a0b94ec8ce8b40
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05719141
反応ノート
読み込み中…