Methyl iodide → 3-Methoxyquinoline

HRID 863280

反応式

HRID 863280 の反応式
[C:1](=O)([O-])[O-].[K+].[K+].CI.[OH:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2>CN(C)C=O.C(OCC)C>[CH3:1][O:9][C:10]1[CH:11]=[N:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2

参加物

6

反応物 3

HCID 6328Methyl iodideHCID 113763-HydroxyquinolineHCID 11430Potassium Carbonate

生成物 1

HCID 5758073-Methoxyquinoline

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

1.05 g of anhydrous potassium carbonate and 0.48 ml of methyliodide are added to a solution of 1.0 g of 3-hydroxyquinoline in 8.5 ml of dimethylformamide and the reaction mixture is stirred at room temperature for 18 h. It is diluted with diethyl ether, the resulting suspension is filtered and the filtrate is concentrated. The crude product is purified by FC over 60 g of silica gel (mobile phase F) to give 3-methoxyquinoline: Rf (A)=0.53.

後処理

  1. filtrationthe resulting suspension is filtered
  2. concentrationthe filtrate is concentrated
  3. customThe crude product is purified by FC over 60 g of silica gel (mobile phase F)

出典と根拠

ORDレコード
ord-8ee420d42c2148ab89a0b94ec8ce8b40
出典データセット
uspto-grants-1998_02
特許番号
US05719141

関連ノート

読み込み中…