Methanol → HCID 19697816、化合物
反応式
C([O:3][C:4]([CH:6]1[CH2:11][NH:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7]1)=O)C.[BH4-].[Li+].CO>O1CCCC1>[OH:3][CH2:4][CH:6]1[CH2:11][NH:10][C:9]2[CH:12]=[CH:13][CH:14]=[CH:15][C:8]=2[S:7]1参加物
5
実験手順
1.6 g of 2(R,S)-ethoxycarbonyl-3,4-dihydro-2H1,4-benzothiazine are reacted with 1.06 g of lithium borohydride in 20 ml of tetrahydrofuran. After addition of 10 ml of methanol, the mixture is concentrated and the residue is purified by means of FC over 80 g of silica gel (mobile phase S). This gives the title compound: Rf (S)=0.29.
後処理
- concentrationthe mixture is concentrated
- customthe residue is purified by means of FC over 80 g of silica gel (mobile phase S)
出典と根拠
- ORDレコード
- ord-934ec0e0f6a147068fbacf6cdc8da363
- 出典データセット
- uspto-grants-1998_02
- 特許番号
- US05719141
反応ノート
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