Ethanol → HCID 54318922、化合物

HRID 863634ノート

反応式

HRID 863634 の反応式
[C:1]([C:11]1[N:15](C)[C:14]([CH2:17][C:18]([O:20]C)=[O:19])=[CH:13][CH:12]=1)(=[O:10])[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[OH-].[Na+].[CH2:24](O)C.C(C1N(C)C(CC(O)=O)=CC=1)(=O)C1C=CC(OC)=CC=1>O>[C:1]([C:11]1[NH:15][C:14]([CH2:17][C:18]([OH:20])=[O:19])=[C:13]([CH3:24])[CH:12]=1)(=[O:10])[C:2]1[CH:3]=[CH:4][C:5]([O:8][CH3:9])=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 18424261Methyl [5-(4-methoxybenzoyl)-1-methyl-1H-pyrrol-2-yl]acetateHCID 20566121HCID 20566121、化合物

生成物 1

HCID 54318922HCID 54318922、化合物収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 3.00 g. (0.0105 mole) of methyl 5-(ρ-anisoyl)-1-methylpyrrole-2-acetate in 12 ml. (0.012 mole) of 1N sodium hydroxide solution and 5 ml. of 95% ethanol is refluxed for 30 minutes. The solution is diluted with water and the ethanol is evaporated in vacuo. The solution is filtered, and the filtrate acidified with dilute hydrochloric acid. The precipitated solid is collected by filtration, dried and recrystallized from methanol-water to give about 2.4 g. (87% yield) of white-5-(ρ-anisoyl)-1-methylpyrrole-acetic acid, M.P. 170°-171° C.

後処理

  1. customthe ethanol is evaporated in vacuo
  2. filtrationThe solution is filtered
  3. filtrationThe precipitated solid is collected by filtration
  4. customdried
  5. customrecrystallized from methanol-water
  6. customto give about 2.4 g

出典と根拠

ORDレコード
ord-db14e6ff4a1c4bcf8f6672b2cbc07878
出典データセット
uspto-grants-1998_02
特許番号
US05721347

反応ノート

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