Poly(oxy-1,2-ethanediyl), α-(2-azidoethyl)-ω-(2-azidoethoxy)- → Bis-Aminoethylglycol

HRID 863735

反応式

HRID 863735 の反応式
[N:1]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][N:12]=[N+]=[N-])=[N+]=[N-].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH2:1][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH2:12]

参加物

4

反応物 2

HCID 10845705Poly(oxy-1,2-ethanediyl), α-(2-azidoethyl)-ω-(2-azidoethoxy)-HCID 21226445Aluminium lithium hydride

生成物 1

HCID 70248Bis-Aminoethylglycol収率 97%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

The diazide (17) (3.55 g, 17.85 mmol) in THF (10mL) was added dropwise into a cold (-5° C.) stirred mixture of lithium aluminum hydride (1.83 g, 48.2 mmol) in THF (20 mL). The reaction mixture was kept at -5° C. and carefully quenched with water (10 mL). The THF layer was filtered to remove the inorganic salts, dried over Na2SO4, and evaporated in vacuo to afford the diamine (18) (2.56 g, 97% yield).

後処理

  1. customwas kept at -5° C.
  2. customcarefully quenched with water (10 mL)
  3. filtrationThe THF layer was filtered
  4. customto remove the inorganic salts
  5. dry with materialdried over Na2SO4
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-7b18f818422b45a7b79aa84b48553855
出典データセット
uspto-grants-1996_10
特許番号
US05561042

関連ノート

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