Sodium Iodide → 6-Phenyl-1-hexyl iodide

HRID 863840ノート

反応式

HRID 863840 の反応式
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=O)=O.[I-:18].[Na+]>CC(C)=O>[C:12]1([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][I:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 130797026-Phenylhex-1-yl methylsulfonate

生成物 1

HCID 145296726-Phenyl-1-hexyl iodide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To 6-phenylhex-1-yl methylsulfonate (4.55 g; 17.3 mmol) dissolved in acetone (100 ml) is added sodium iodide (2.5 g; 173 mmol) and the reaction mixture is heated 2 hours at reflux. The reaction mixture is then concentrated to dryness and partitioned between ether and water. The organic phase is separated, dried, concentrated to dryness and purified with silica chromatography using 10 EtOAc/90 petroleum ether to give 6-phenyl-1-hexyl iodide as a colorless oil which is used directly in Step F.

後処理

  1. temperaturethe reaction mixture is heated 2 hours
  2. temperatureat reflux
  3. concentrationThe reaction mixture is then concentrated to dryness
  4. custompartitioned between ether and water
  5. customThe organic phase is separated
  6. customdried
  7. concentrationconcentrated to dryness
  8. custompurified with silica chromatography

出典と根拠

ORDレコード
ord-8f17090b939c4349a5cc3b771a243771
出典データセット
uspto-grants-1996_10
特許番号
US05561143

反応ノート

読み込み中…