2,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole → 2,3-dihydro-6-methoxy-1H-isoindol-5-ol

HRID 863908

反応式

HRID 863908 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH2:13]C1C=CC=CC=1)[CH2:8][N:7](CC1C=CC=CC=1)[CH2:6]2>[OH-].[OH-].[Pd+2].C(O)C>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][CH2:8]2)=[CH:4][C:3]=1[OH:2]

参加物

4

反応物 1

HCID 107363032,3-Dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole

生成物 1

HCID 102411352,3-dihydro-6-methoxy-1H-isoindol-5-ol収率 87.4%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

To 35 mL of ethyl alcohol is added 0.5 g of 2,3-dihydro-5-methoxy-6-(phenylmethoxy)-2-(phenylmethyl)-1H-isoindole. The solution is warmed until everything is dissolved. The solution is cooled to room temperature and 0.13 g of 35% palladium hydroxide on carbon is added. The resulting mixture is shaken on a Parr apparatus at 50 pounds per square inch for 21 hours. The solution is filtered through a pad of diatomaceous earth and the pad washed with ethyl alcohol. The volatiles are removed to afford 0.209 g of the desired product as a tan solid.

後処理

  1. temperatureThe solution is warmed until everything
  2. dissolutionis dissolved
  3. filtrationThe solution is filtered through a pad of diatomaceous earth
  4. washthe pad washed with ethyl alcohol
  5. customThe volatiles are removed

出典と根拠

ORDレコード
ord-888796b656fa43f49d687edd5038dc64
出典データセット
uspto-grants-1996_10
特許番号
US05561141

関連ノート

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