Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate → Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

HRID 864306ノート

反応式

HRID 864306 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([N+:7]([O-])=O)[CH:4]=[C:3]1[C:10]([O:12][CH2:13][CH3:14])=[O:11]>C(O)C.[Pt]>[NH2:7][C:5]1[CH:4]=[C:3]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:2]([CH3:1])[CH:6]=1

参加物

4

反応物 1

HCID 10442704Ethyl 1-methyl-4-nitro-1H-pyrrole-2-carboxylate

生成物 1

HCID 11182847Ethyl 4-amino-1-methyl-1H-pyrrole-2-carboxylate

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 702Ethanol溶媒

実験手順

Ethyl 1-methyl-4-nitro-2-pyrrolecarboxylate (16.0 g, 0.081 mol) (M. J. Weiss, J. S. Webb and J. M. Smith, J. Amer. Chem. Soc., 79, 1266 (1957)) is dissolved in (200 mL) ethanol and (1.60 g) of 10% platinum on carbon is then added. The mixture is shaken for 16 hours in a PARR hydrogenator. The catalyst is removed by filtration through a pad of celite and the filtrate is concentrated in vacuo to a yellow oil. The oil is carried on directly without purification.

後処理

  1. customThe catalyst is removed by filtration through a pad of celite
  2. concentrationthe filtrate is concentrated in vacuo to a yellow oil
  3. customdirectly without purification

出典と根拠

ORDレコード
ord-bac660030f24401ca8087bfbf79e73f6
出典データセット
uspto-grants-1996_10
特許番号
US05563113

反応ノート

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