1-Boc-4-(2-nitrophenyl)piperazine → tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate

HRID 864384ノート

反応式

HRID 864384 の反応式
[CH3:1][C:2]([CH3:22])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[N+:19]([O-])=O)[CH2:9][CH2:8]1)=[O:6])[CH3:3]>C(O)C.[Pd]>[CH3:3][C:2]([CH3:22])([O:4][C:5]([N:7]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH2:19])[CH2:9][CH2:8]1)=[O:6])[CH3:1]

参加物

4

反応物 1

HCID 219352101-Boc-4-(2-nitrophenyl)piperazine

生成物 1

HCID 2795530tert-Butyl 4-(2-aminophenyl)piperazine-1-carboxylate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine (PREPARATION 12, 7.61 g) is dissolved in ethanol (150 ml). Palladium on carbon (10%, 0.75 g) is added and the reaction is hydrogenated at 45 psi for 6 hr. The mixture is filtered thru celite and concentrated under reduced pressure to give the title compound.

後処理

  1. filtrationThe mixture is filtered thru celite
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d734103bf569437b8a5ede11b22963ff
出典データセット
uspto-grants-1996_10
特許番号
US05563142

反応ノート

読み込み中…