Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate → ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate

HRID 864673

反応式

HRID 864673 の反応式
[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([N+:11]([O-])=O)[N:8]=[CH:7]1)[CH3:2].[H][H]>[Pd]>[CH2:1]([O:3][C:4](=[O:20])[CH:5]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[N:6]1[CH:10]=[C:9]([NH2:11])[N:8]=[CH:7]1)[CH3:2]

参加物

4

反応物 2

HCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 15222343ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate収率 100.5%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

A mixture of 5.9 g of 4-nitro-α-hexyl-1H-imidazole-1-acetic acid ethyl ester, 3 g of palladium-on-carbon and 150 ml of absolute alcohol were subjected to catalytic hydrogenation. Both theoretical and actual hydrogen uptake was 73 pounds. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 5.3 g of the desired title intermediate which was used directly.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-67ed31b84955402790252a01d00d41c0
出典データセット
uspto-grants-1996_10
特許番号
US05563278

関連ノート

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