Trifluoroacetic acid → Trifluoroacetate

HRID 864785ノート

反応式

HRID 864785 の反応式
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:14]([NH:16][C@H:17]([C:25]([O:27][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[O:26])[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[NH2:1][C@H:2]([C:14]([NH:16][C@H:17]([C:25]([O:27][CH2:28][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=1)=[O:26])[CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)=[O:15])[CH2:3][C:4](=[O:13])[O:5][CH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[F:42][C:43]([F:48])([F:47])[C:44]([O-:46])=[O:45]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 10437796Boc-L-Asp(OBzl)-L-Phe-OBzl

生成物 2

HCID 84468TrifluoroacetateHCID 10004433L-Asp(OBzl)-L-Phe-OBzl

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Boc-L-Asp(OBzl)-L-Phe-OBzl (9.91 g) was dissolved in a mixture of trifluoroacetic acid (50 ml) and dichloromethane (50 ml). The resultant solution was stored at room temperature for 2 hr. The reaction mixture was evaporated to dryness to yield a residue which was triturated with ether, collected, washed thoroughly with ether and dried under high vacuum to yield L-Asp(OBzl)-L-Phe-OBzl, trifluoroacetate salt (8.36 g) as a white solid: NMR (CDCl3) δ2.88 (2H, m), 3.07 (2H, m), 4.33 (1H, m), 4.78 (1H, m), 5.02 (2H, s), 5.06 (2H, q), 6.20 (3H, v. br), 7.04 (2H, m), 7.26 (13H, m), 7.65 (1H, d); m/Z 461 (M +H)+.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. customto yield a residue which
  3. customwas triturated with ether
  4. customcollected
  5. washwashed thoroughly with ether
  6. customdried under high vacuum

出典と根拠

ORDレコード
ord-bf38199413a649d99841cecc956ed43d
出典データセット
uspto-grants-1996_10
特許番号
US05563141

反応ノート

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