HCID 18918301、化合物 → Ethyl 3-(4-hydroxyphenoxy)butyrate

HRID 864863ノート

反応式

HRID 864863 の反応式
C([O:8][C:9]1[CH:23]=[CH:22][C:12]([O:13][CH:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([O:13][CH:14]([CH3:21])[CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:22][CH:23]=1

参加物

5

反応物 2

HCID 18918301HCID 18918301、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 18918541Ethyl 3-(4-hydroxyphenoxy)butyrate収率 93.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of the product of step (i) (4.5 g) in absolute ethanol (200 ml) was added 10% palladium-on-charcoal catalyst (1.2 g) and the resulting suspension hydrogenated at ambient temperature and pressure until uptake of hydrogen ceased. The catalyst was removed by filtration through celite and the filtrate was concentrated in vacuo to give ethyl 3-(4-hydroxyphenoxy)butyrate as a low-melting crystalline solid (3.0 g) NMR (d6DMSO): δ1.25 (3H,t); 1.8-2.0 (2H,m); 2.5 (2H,t); 3.9 (2H,t); 4.1 (2H,q); 6.7 (4H,m); 8.8 (1H,br.s); m/e 224 (M)+.

後処理

  1. customhydrogenated at ambient temperature
  2. customThe catalyst was removed by filtration through celite
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-e22b9a3e3f6e40e198ef5a229e9e4fa1
出典データセット
uspto-grants-1996_10
特許番号
US05563141

反応ノート

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