N-bromobutanimide → HCID 18941095、化合物

HRID 865107

反応式

HRID 865107 の反応式
[CH3:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1.[Br:15]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>[Br:15][CH2:1][C:2]1[S:3][C:4]2[CH:14]=[CH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[C:5]=2[N:6]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 75892Naphtho[1,2-d]thiazole, 2-methyl-

生成物 1

HCID 18941095HCID 18941095、化合物収率 63%

試薬・触媒・溶媒 2

HCID 7187Benzoyl Peroxide触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To 3.98 g of 2-methylnaphtho[1,2-d]thiazole dissolved in carbon tetrachloride (40 ml) was added 3.56 g of N-bromosuccinimide and 0.20 g of benzoyl peroxide, followed by 6 hours of heating under reflux. After cooling the reaction solution, insoluble matter was removed by filtration, and the solvent was evaporated. The residue was subjected to silica gel column chromatography eluted with hexane-chloroform (5:1) to obtain 3.50 g (63%) of 2-bromomethylnaphtho[1,2-d]thiazole.

後処理

  1. temperatureof heating
  2. temperatureunder reflux
  3. temperatureAfter cooling the reaction solution, insoluble matter
  4. customwas removed by filtration
  5. customthe solvent was evaporated
  6. washeluted with hexane-chloroform (5:1)

出典と根拠

ORDレコード
ord-13d380465b7a413fade7138bad7130a2
出典データセット
uspto-grants-1996_10
特許番号
US05565479

関連ノート

読み込み中…