Water → Erythromycin trans-traumatate

HRID 865829

反応式

[C:1]([OH:16])(=[O:15])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13].[CH3:17][CH2:18][C@H:19]1[O:34][C:32](=[O:33])[C@H:31]([CH3:35])[C@@H:30]([O:36][C@@H:37]2[O:42][C@@H:41]([CH3:43])[C@H:40]([OH:44])[C@@:39]([O:46][CH3:47])([CH3:45])[CH2:38]2)[C@H:29]([CH3:48])[C@@H:28]([O:49][C@@H:50]2[O:55][C@H:54]([CH3:56])[CH2:53][C@H:52]([N:57]([CH3:59])[CH3:58])[C@H:51]2[OH:60])[C@@:27]([OH:62])([CH3:61])[CH2:26][C@@H:25]([CH3:63])[C:23](=[O:24])[C@H:22]([CH3:64])[C@@H:21]([OH:65])[C@@:20]1([OH:67])[CH3:66].O>O.C(O)C>[CH3:17][CH2:18][C@H:19]1[O:34][C:32](=[O:33])[C@H:31]([CH3:35])[C@@H:30]([O:36][C@@H:37]2[O:42][C@@H:41]([CH3:43])[C@H:40]([OH:44])[C@@:39]([O:46][CH3:47])([CH3:45])[CH2:38]2)[C@H:29]([CH3:48])[C@@H:28]([O:49][C@@H:50]2[O:55][C@H:54]([CH3:56])[CH2:53][C@H:52]([N:57]([CH3:58])[CH3:59])[C@H:51]2[OH:60])[C@@:27]([OH:62])([CH3:61])[CH2:26][C@@H:25]([CH3:63])[C:23](=[O:24])[C@H:22]([CH3:64])[C@@H:21]([OH:65])[C@@:20]1([OH:67])[CH3:66].[C:1]([O-:16])(=[O:15])/[CH:2]=[CH:3]/[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][C:12]([O-:14])=[O:13]

参加物

反応条件

温度: 4 °C

実験手順

2.28 g of trans-traumatic acid (10 mmol) are suspended in 100 ml of water/ethanol 2:1 mixture at 4° C. 14.7 g of erythromycin free base (20 mmol) are added and the resulting mixture is kept under stirring at 4° C. for 3 hours and then heated to 25° C. overnight. 200 ml water ape then added. The mixture is concentrated under vacuum to a volume of about 100 ml and cooled to 4° C.

後処理

customat 4° C
temperatureheated to 25° C. overnight
concentrationThe mixture is concentrated under vacuum to a volume of about 100 ml
temperaturecooled to 4° C.

出典と根拠

ORDレコード: ord-7ba1ff068ad0401285a0594e6107f038
出典データセット: uspto-grants-1996_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05567716

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート