関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Erythromycin | HCID 12560 | — |
| 反応物 | Traumatic Acid | HCID 5283028 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | Erythromycin trans-traumatate | HCID 131719629 | — |
反応手順
2.28 g of trans-traumatic acid (10 mmol) are suspended in 100 ml of water/ethanol 2:1 mixture at 4° C. 14.7 g of erythromycin free base (20 mmol) are added and the resulting mixture is kept under stirring at 4° C. for 3 hours and then heated to 25° C. overnight. 200 ml water ape then added. The mixture is concentrated under vacuum to a volume of about 100 ml and cooled to 4° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05567716 |
|---|
| 出典データセット | uspto-grants-1996_10 |
|---|
| ORD ID | ord-7ba1ff068ad0401285a0594e6107f038 |
|---|
| 出典メモ | uspto-grants-1996_10 |
|---|
