HCID 22850139、化合物 → HCID 22850137、化合物
反応式
[N:1]([CH2:4][C@H:5]([OH:15])[CH2:6][P:7]([CH3:14])(=[O:13])[O:8][CH2:9][CH:10]([CH3:12])[CH3:11])=[N+]=[N-].[H][H]>C(O)C.[Pd]>[NH2:1][CH2:4][C@H:5]([OH:15])[CH2:6][P:7]([CH3:14])(=[O:13])[O:8][CH2:9][CH:10]([CH3:12])[CH3:11]参加物
5
実験手順
To a solution of 1.2 g of isobutyl P-[3-azido-2(S)- hydroxy-propyl]-P-methyl-phosphinate in 25 ml of ethanol are added 0.25 g of 5% palladium on charcoal. The resulting mixture is hydrogenated at 1 bar until hydrogen uptake ceases. The mixture is then filtered and the filtrate evaporated to give isobutyl P-[3-amino-2(S)-hydroxy-propyl]-P-(methyl)-phosphinate as a viscous oil, 31P-NMR spectrum: δ=+55.6 and +54.6 ppm (CDCl3), [α]D25 =+10.9 (c=0.50% in ethanol).
後処理
- filtrationThe mixture is then filtered
- customthe filtrate evaporated
出典と根拠
- ORDレコード
- ord-18541933a384442a9a5dd5a5d21ce2ec
- 出典データセット
- uspto-grants-1996_10
- 特許番号
- US05567840
反応ノート
読み込み中…