Water → N-ethyl-4-fluoroaniline

HRID 865928ノート

反応式

HRID 865928 の反応式
I[CH2:2][CH3:3].[F:4][C:5]1[CH:11]=[CH:10][C:8]([NH2:9])=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[CH2:2]([NH:9][C:8]1[CH:10]=[CH:11][C:5]([F:4])=[CH:6][CH:7]=1)[CH3:3]

参加物

6

反応物 4

HCID 962WaterHCID 6340IodoethaneHCID 97314-FluoroanilineHCID 11430Potassium Carbonate

生成物 1

HCID 4962184N-ethyl-4-fluoroaniline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Iodoethane (3.6 ml) was added to a mixture of 4-fluoroaniline (4.26 ml) and potassium carbonate (6.9 g) in dry DMF (100 ml). After 18.5 h at 23°, the resulting suspension was poured into water (400 ml) and extracted with EA (400 ml). The organic extract was washed with water (200 ml) then saturated brine (200 ml), dried and evaporated. The residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent to give the title compound (3.667 g) as a yellow oil.

後処理

  1. extractionextracted with EA (400 ml)
  2. extractionThe organic extract
  3. washwas washed with water (200 ml)
  4. dry with materialsaturated brine (200 ml), dried
  5. customevaporated
  6. customThe residual oil was chromatographed with 2 to 3 to 4% EA in hexane as eluent

出典と根拠

ORDレコード
ord-f3ee23012faf4bc980a61779569cdba7
出典データセット
uspto-grants-1996_10
特許番号
US05569654

反応ノート

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