Nitric Acid → 2-(3-Methyl-4-nitrophenyl)benzonitrile

HRID 866264

反応式

HRID 866264 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][CH:7]=1.[N+:16]([O-])([OH:18])=[O:17].S(=O)(=O)(O)O>O>[CH3:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=2[C:10]#[N:11])[CH:5]=[CH:6][C:7]=1[N+:16]([O-:18])=[O:17]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 13942432-(3-Methylphenyl)benzonitrile

生成物 1

HCID 214689052-(3-Methyl-4-nitrophenyl)benzonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2-(3-Methylphenyl)benzonitrile (18.1 mmoles, 3.5 g) was added slowly at -5° C. to a mixture of 10 ml nitric acid and 10 ml sulfuric acid. After 5 minutes, the reaction was diluted with cold water. The solid was collected, dissolved in THF. The solution was dried and concentrated. The solid was recrystallized from ether and hexane to yield 2.45 g of 2-(3-methyl-4-nitrophenyl)benzonitrile. (MS)

後処理

  1. customThe solid was collected
  2. dissolutiondissolved in THF
  3. customThe solution was dried
  4. concentrationconcentrated
  5. customThe solid was recrystallized from ether and hexane

出典と根拠

ORDレコード
ord-3c1b5786e2664901890ebc993329f284
出典データセット
uspto-grants-1996_10
特許番号
US05569768

関連ノート

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