Ethanol → 4-(Benzyloxy)benzoic acid

HRID 866389

反応式

HRID 866389 の反応式
N[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)=[O:3].C([OH:20])C>[OH-].[Na+]>[C:2]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[CH:6][CH:5]=1)([OH:20])=[O:3]

参加物

4

反応物 2

HCID 702EthanolHCID 27264314-Benzyloxybenzamide

生成物 1

HCID 738804-(Benzyloxy)benzoic acid

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of 4-aminocarbonylphenoxy phenyl methane (10g) in ethanol (100ml) and sodium hydroxide (100ml., 10N) was heated under reflux with vigorous stirring for 24hrs. The reaction mixture was cooled, the precipitated sodium salt was filtered off washed with a little water then converted to 4-carboxyphenoxy phenyl methane by boiling under reflux with concentrated hydrochloric acid (100ml) for 6hr. Dilution of the cooled mixture and extraction with ether yielded 4-carboxyphenoxy phenyl methane, m.p. 188°.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe precipitated sodium salt was filtered off
  5. washwashed with a little water
  6. temperatureunder reflux with concentrated hydrochloric acid (100ml) for 6hr
  7. extractionDilution of the cooled mixture and extraction with ether

出典と根拠

ORDレコード
ord-628d7530e92b4426b5db4ef6ae9a0596
出典データセット
uspto-grants-1978_07
特許番号
US04098816

関連ノート

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