Water → alpha-Hydroxy[2-(beta,beta,beta-trichloroethoxycarbonyl)aminothiazol-4-yl]acetonitrile

To a mixture of 1.0 g. of 2-(β,β,β-trichloroethoxycarbonyl)amino-4-formylthiazole, 0.87 g. of KH2PO4, 6 ml. of water and 4 ml. of dimethylformamide is added 0.33 g. of KCN at room temperature and the mixture is stirred for 30 minutes. The reaction mixture is extracted with ethyl acetate and the ethyl acetate layer is washed with water and dried. Evaporation of ethyl acetate gives α-hydroxy-[2-(β,β,β-trichloroethoxycarbonyl)aminothiazol-4-yl]-acetonitrile 1.127 g.

1. additionTo a mixture of 1.0 g
2. extractionThe reaction mixture is extracted with ethyl acetate
3. washthe ethyl acetate layer is washed with water
4. customdried
5. customEvaporation of ethyl acetate

ORDレコード

ord-8a90cc63c1364b6e8d0b7c0f087b0172

出典データセット

uspto-grants-1978_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04098888